In particular 4 clinical trials in this setting did show similar
efficacy to the other hormonal agents (aromatase inhibitors and
tamoxifen) with good tolerability profile.Fulvestrant(s) had a
lower incidence of joint disorders.
Many breast cancers are stimulated to grow by the female sex
hormones oestrogen and progesterone. These breast cancers are
called hormone sensitive or hormone receptor positive. Drugs that
block the effects of these hormones can slow or stop the growth of
the breast cancer cells. Fulvestrant(s) stops oestrogen getting to
the cancer cells by blocking oestrogen receptors and reducing the
number of receptors the cancer cell has.
Fulvestrant is a selective estrogen receptor down-regulator (SERD).
Fulvestrant is indicated for the treatment of hormone receptor
positive metastatic breast cancer in postmenopausal women with
disease progression following anti-estrogen therapy. The dosing
schedule for fulvestrant remains under investigation in an attempt
to optimize its effectiveness.
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