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17a Hydroxyprogesterone Pharmaceutical Raw Materials CAS 68-96-2 White Crystalline Powder

Categories Pharmaceutical Raw Materials
Brand Name: TINGYI
Model Number: CAS: 68-96-2
Certification: GMP , ISO 9001:2008
Place of Origin: CHINA
MOQ: 10g
Price: Contact Us
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 3000KG/Month
Delivery Time: Usually within 7 work days
Packaging Details: Stealth and discreet packaging
Product Name: 17A-hydroxyprogesterone
CAS: 68-96-2
MF: C21H30O3
MW: 330.4611
Assay: 99%
Appearance: White crystalline powder
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    17a Hydroxyprogesterone Pharmaceutical Raw Materials CAS 68-96-2 White Crystalline Powder

    Product Name: 17A-hydroxyprogesterone


    Product Details:



    Product Name


    17A-hydroxyprogesterone

    Alias

    17-Hydroxyprogesterone; 17a-Hydroxypregn-4-ene-3,20-dione; 17-Alpha-Hydroxy-Progesterone; 17-alpha-hydroxypregn-4-ene-3,20-dione; 17-hydroxypregn-4-ene-3,20-dione; 4-Pregnen-17a-ol-3,20-dione; Hydroxyprogesterone; 17α-Hydroxy Progesterone; 17a-Hydroxy Progesterone


    MF


    C21H30O3


    MW


    330.4611


    CAS


    68-96-2


    EINECS


    200-699-4


    Melting point


    276 ºC


    Assay


    99%

    Molecular Structure

    Appearance


    White crystalline powder


    Descriptions:


    17α-Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate. It is an ester derivative of 17α-hydroxyprogesterone formed from caproic acid (hexanoic acid).
    17α-Hydroxyprogesterone (17α-OHP), or hydroxyprogesterone (OHP) (INN, BAN), also known as 17α-hydroxypregn-4-ene-3,20-dione, is an endogenous progestogen steroid hormone related to progesterone. 17A-hydroxyprogesterone is also a chemical intermediate in the biosynthesis of many other endogenous steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids, as well as neurosteroids.

    The 17-hydroxyprogesterone (17-OHP) test is routinely ordered as part of newborn screening in the UnitedStates to detect congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. CAH is a group of inherited disorders caused by specific gene mutations and associated with cortisol-related enzyme deficiencies. About 90% of CAH cases are caused by a mutation in the 21-hydroxylase gene (also called P450c1 or CYP21A2) and may be detected due to the accumulation of 17-OHP in the blood. The 17-OHP test may be used to screen for CAH in older children or adults before symptoms appear or to confirm a CAH diagnosis in people with symptoms.
    17-OHP testing may produce false-positive test results. If the level is elevated but not so high that it is diagnostic of CAH, other tests may be performed, such as androstenedione and testosterone. An ACTH stimulation test may be also be ordered as a follow-up test (in CAH, ACTH stimulation will markedly increase 17-OHP levels). Molecular genetic testing may be performed to detect CYP21A2 gene mutations thatcan cause the condition. A karyotype test may be ordered as a follow-up test to detect chromosome disorders and to help determine a baby's sex. Electrolytes may be ordered to measure the person's sodium and potassium levels.


    Application:


    17a-Hydroxyprogesterone is used in women who are pregnant with a single baby, and who have delivered a baby too early (preterm) in the past. It is used to help lower the risk of having a preterm baby again. Hydroxyprogesterone is a man-made form of a female hormone (progestin). It is not known how it works to prevent preterm labor. 17a-Hydroxyprogesterone is not intended to prevent preterm birth in women pregnant with more than one baby (such as twins, triplets). It is also not intended to stop active preterm labor. 17α-OHP increases in the third trimester of pregnancy primarily due to fetal adrenal production. This steroid is primarily produced in the adrenal glands and to some degree in the gonads, specifically the corpus luteum of the ovary. Normal levels are 3-90 ng/dl in children, and in women, 20-100 ng/dl prior to ovulation, and 100-500 ng/dl during the luteal phase.

    The 17-hydroxyprogesterone (17-OHP) test is routinely ordered as part of newborn screening in the UnitedStates to detect congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. CAH is a group ofinherited disorders caused by specific gene mutations and associated with cortisol-related enzymedeficiencies. About 90% of CAH cases are caused by a mutation in the 21-hydroxylase gene (also calledP450c1 or CYP21A2) and may be detected due to the accumulation of 17-OHP in the blood. The 17-OHP test may be used to screen for CAH in older children or adults before symptoms appear or toconfirm a CAH diagnosis in people with symptoms.



    COA:



    Items


    Standard


    Resutls


    Description


    White or almost white crystalline powder, odorless


    Conforms


    Solubility


    insoluble in water, solube in ether, slightly soluble in benzene


    Conforms


    Specific Optical Rotation


    +58°---+64° (1% chloroform Solution)


    60.3°


    Melting Point


    about 120 -124 ºC


    123ºC


    Water


    ≤0.1%


    0.05%


    Free N-Caproic Acid


    ≤0.58%


    0.20%


    Ordinary Impurities


    ≤2.0%


    conforms


    Residual Solvents


    Methanol ≤ 3000PPM


    1280PPM


    Ethanol≤5000PPM


    1500PPM


    Dichloromethane ≤ 600PPM


    80PPM


    Assay


    97.0%--103.0%


    99.30%


    Conclusion


    Conforms to USP31.


    Our Company Advantages:


    1, High quality with competitive price:

    1) Standard: U.S Standard
    2) All Purity≥99.8%
    3) We are manufacturer and can provide high quality products with factory price.


    2, Fast and safe delivery
    1) Parcel can be sent out within 8 hours after payment. Tracking number available
    2) Secure and discreet shipment. Various transportation methods for your choice.
    3) Customs pass rate ≥99.8%
    4)We provide re-ship policy.
    5) We have warehouse in Australia, Canada and England, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse!
    3, We have clients throughout the world.
    1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
    2) Meeting customers's requirement is our responsibility.
    3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.


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    Quality 17a Hydroxyprogesterone Pharmaceutical Raw Materials CAS 68-96-2 White Crystalline Powder for sale
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