AROMASIN Tablets for oral administration contain 25 mg of
exemestane, an irreversible, steroidal aromatase inactivator.
Exemestane is chemically described as
6-methylenandrosta-1,4-diene-3,17-dione.The active ingredient is a
white to slightly yellow crystalline powder with a molecular weight
of 296.41.Exemestane is freely soluble in N, N-dimethylformamide,
soluble in methanol, and practically insoluble in water.
This medication is used to treat certain types of breast cancer
(such as hormone-receptor-positive breast cancer) in women after
menopause. Exemestane is also used to help prevent the cancer from
returning. Some breast cancers are made to grow faster by a natural
hormone called estrogen.Exemestane decreases the amount of estrogen
the body makes and helps to slow or reverse the growth of these
Mechanism Of Action:
Exemestane is an irreversible, steroidal aromatase inactivator,
structurally related to the natural substrate androstenedione. It
acts as a false substrate for the aromatase enzyme, and is
processed to an intermediate that binds irreversibly to the active
site of the enzyme, causing its inactivation, an effect also known
as "suicide inhibition."
Exemestane significantly lowers circulating estrogen concentrations
in postmenopausal women, but has no detectable effect on adrenal
biosynthesis of corticosteroids or aldosterone. Exemestane has no
effect on other enzymes involved in the steroidogenic pathway up to
a concentration at least 600 times higher than that inhibiting the
Treatment by Condition Related to exemestane:
Hormone Receptor Positive Postmenopausal Early Breast Cancer After
Adjuvant Tamoxifen Medications;
Breast Cancer that has Spread to Another Part of the Body
Medications;Prevention of Breast Cancer Medications;Advanced Breast
Cancer Progression Post-Antiestrogen Therapy Medications
How to use exemestane?
Take this medication by mouth, usually once daily with food (after
a meal), or as directed by your doctor.
Dosage is based on your medical condition, response to treatment,
and other medications you may be taking. Be sure to tell your
doctor and pharmacist about all the products you use (including
prescription drugs, nonprescription drugs, and herbal products).Use
this medication regularly to get the most benefit from it. To help
you remember, take it at the same time each day.
Hot flashes, hair loss, joint/bone/muscle pain, tiredness, unusual
sweating, nausea, diarrhea, dizziness, and trouble sleeping may